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anti-lgr5 adc mc-vc-pab-mmae  (Genentech inc)

 
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    Genentech inc anti-lgr5 adc mc-vc-pab-mmae
    Anti Lgr5 Adc Mc Vc Pab Mmae, supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/vc-mmae+adcs/pmc11270908-221-18-0?v=Genentech+inc
    Average 90 stars, based on 1 article reviews
    anti-lgr5 adc mc-vc-pab-mmae - by Bioz Stars, 2026-07
    90/100 stars

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    ADCs, targets, and tumor indications of eight vc-MMAE ADCs included in the analysis.

    Journal: mAbs

    Article Title: Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

    doi: 10.1080/19420862.2019.1699768

    Figure Lengend Snippet: ADCs, targets, and tumor indications of eight vc-MMAE ADCs included in the analysis.

    Article Snippet: Over the past decade, Genentech has developed eight vc-MMAE ADCs, against different targets and for diverse tumor indications, which provides a unique opportunity to characterize the clinical pharmacology for this class of ADCs.

    Techniques:

    PK parameters (mean ± SD [%CV]) of acMMAE, total antibody and unconjugated MMAE post the first dose of vc-MMAE ADCs at 2.4 mg/kg (90 min IV infusion).

    Journal: mAbs

    Article Title: Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies

    doi: 10.1080/19420862.2019.1699768

    Figure Lengend Snippet: PK parameters (mean ± SD [%CV]) of acMMAE, total antibody and unconjugated MMAE post the first dose of vc-MMAE ADCs at 2.4 mg/kg (90 min IV infusion).

    Article Snippet: Over the past decade, Genentech has developed eight vc-MMAE ADCs, against different targets and for diverse tumor indications, which provides a unique opportunity to characterize the clinical pharmacology for this class of ADCs.

    Techniques:

    A list of parameters used to build the cellular disposition model for MMAE and T-vc-MMAE

    Journal: Drug Metabolism and Disposition

    Article Title: Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE

    doi: 10.1124/dmd.117.076414

    Figure Lengend Snippet: A list of parameters used to build the cellular disposition model for MMAE and T-vc-MMAE

    Article Snippet: T-vc-MMAE ADC was synthesized by conjugating trastuzumab (Herceptin; Genentech/Roche, South San Francisco, CA) with the vc-MMAE drug-linker using the random conjugation method.

    Techniques: Concentration Assay, Binding Assay, Formulation

    A list of parameters used to build the cellular disposition model for MMAE and T-vc-MMAE

    Journal: Drug Metabolism and Disposition

    Article Title: Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE

    doi: 10.1124/dmd.117.076414

    Figure Lengend Snippet: A list of parameters used to build the cellular disposition model for MMAE and T-vc-MMAE

    Article Snippet: Synthesis and Characterization of Trastuzumab-vc-MMAE T-vc-MMAE ADC was synthesized by conjugating trastuzumab (Herceptin; Genentech/Roche, South San Francisco, CA) with the vc-MMAE drug-linker using the random conjugation method.

    Techniques: Concentration Assay, Binding Assay, Formulation